A lady has felt depressed for a couple of years and have tried different medicat

A lady has felt depressed for a couple of years and have tried different medication to address her feeling of hopelessness and lack of motivation but that did not work. He family Dr. has prescribed iproniazid which has been effective to address many cases of depression by inhibiting an enzyme in the brain called monoamine oxidase (MAO) which is one of the enzymes responsible for catecholamine degradation and its inhibition significantly increases the available concentration of catecholamine. Since iproniazid is a new drug, it potential adverse effect are not well understood, and her Dr. advised her to report any unusual effect of the medication. Following the administration of the medication, she started to feel motivated and energetics for the first time in several years which made her to host a gala wine and cheese reception. The party was well attended but at the end of the party she started having severe headache and nausea. She was rushed to the hospital emergency and the attending physician recorded a blood pressure of 230/160 mmHg. Recognizing that she is experiencing hypertensive emergency, the Dr. administered phentolamine (an α-adrenoceptor antagonist). Her blood pressure quickly normalizes, and the Dr. Subsequent clinical investigation identifies a new and now famous drug-food interaction involving MAO inhibitors. The potential adverse interaction is shared by some other MAO inhibitors. More recent work on subtype-selective and reversible MAO inhibitors has minimized the incidence of this interaction.
Instructions
1. Which enzymes metabolize catecholamines? What are the specificities of isoforms of these enzymes for the various catecholamines?
2. What is the mechanistic explanation for the interaction of MAO inhibitors with red wine and aged cheese?
3. How did phentolamine lower her blood pressure?