I will need a review essay talking about cancer stem cells. Main points: 1. Def

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I will need a review essay talking about cancer stem cells.
Main points:
1. Definition of cancer stem cells, how this concept was identified
2. Plasticity of CSCs
3. Major pathway in CSCs (NOTCH and Wnt/bCatenin)
4. Markers for CSCs
5.CSCs and therapy resistance
6.Therapeutic targeting of CSCs
You can add points that you think is important.
Please read the review papers below.